Overview:Protective Groups in Organic Chemistry - During the past decade there has been a great increase in the use of protective groups, especially in the synthesis of large and complex organic molecules. Perhaps the greatest activity has been in the peptide field where such triumphs as the total synthesis of insulin and of bovine ribonuclease (molecular weight 13,700) have been achieved. Correspondingly, more protective groups have been devised for the protection of amino and imino groups than for any other functional group. There are many reviews and books on the synthesis of pep tides but there has been no general survey of protective groups since my 1 own review in 1963. At that time the five main methods for the removal of protective groups involved acid or base hydrolysis, reduction, oxidation, or thermal elimination reactions. Recent advances include the use of photo-sensitive and metalion sensitive protective groups, and the attachment of functional groups to reactive polymers as a method of protection during the solid-phase synthesis of peptides and polynucleotides. Another interesting development is the design and use of protective groups with a built-in 'safety-catch', which can be 'released' by a specific chemical reaction, so that an otherwise stable bond is made labile at the appropriate moment thereby allowing the protective group to be removed under very 2 mild conditions. My own interest in protective groups dates from 1944 when, as a student, I gave two lectures on the subject and produced an 11 page review including 70 references.

This book is on page /88f0ff300130a9332bf7ee8997e69000/book/1603729708-9781468472202. It was written by the following authors: J. McOmie. Book Protective Groups in Organic Chemistry, which can be read online, published by the company: Springer-Verlag New York Inc.. Other books on similar topics can be found in sections: Science, Technology, Medicine. The book was published on 2012-11-26 00:00:00. It has 418 pages and is published in Paperback format and weight 629 g. File for download Protective Groups in Organic Chemistry has PDF format and is called protective-groups-in-organic-chemistry.pdf. Other books you can download below. Our nottedeiricercatoriaq.it site is not responsible for the content of PDF files.


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